Saint Francis Borgia Regional High School is a Catholic coeducational college preparatory high school located in the town of Washington, Missouri, in  Franklin County about 50 miles southwest of St. Louis. Students come from as many as 20 elementary schools, including both public and private schools.  The geographic region served is centered in Franklin County and ranges from St. Louis County to the east, Gasconade County to the west, Crawford County to the south, and Warren and St. Charles counties to the north.

Spirituality is at the core of life at Borgia.  Students have many opportunities to practice and learn about their Catholic faith and the faith of others. Borgia offers a wide variety of courses from standard core curriculum courses to college credit courses to technical courses taught through a partnership agreement with Four Rivers Technical College. In addition to a rigorous academic program, students have the opportunity to participate in a wide variety of sports and club activities.

Borgia enjoys extraordinary loyalty; legacies of three or more generations are not uncommon.